A study led by scientists at the University of Oxford was conducted on a group of mice to investigate the effect of THC on the central nervous system, more specifically the CB1 and CB2 receptors of the brain. The scientists found that there were varying outcomes to these tests which could possibly reflect the level in the central nervous system that is involved. The researchers found that THC increases immobility, or catalepsy as well as reduction in body temperature. In their later studies they found opposing effects such as higher levels of spontaneous running activity, even when placed in fear-inducing environments such as a maze or open field. They concluded that these outcomes could be based on the alterations of neurotransmitter genes in the motor control center of the brain.
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